Author

Pauline Funchain

Stanford MedicineORCID 0000-0002-7568-8626Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alexis Bernat· 1 shared Allison Betof WarneriD· 1 shared Amanda KiraneiD· 1 shared Calvin Jay KuoiD· 1 shared Emma WagneriD· 1 shared Jay ChadokiyaiD· 1 shared Joshua ArbesmaniD· 1 shared Kevin D. CooperiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Alexis Bernat

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2 papers

Recent·Most cited

Patient-Derived Melanoma Organoids Preserve Tumor-Immune Heterogeneity and Reveal Context-Dependent Responses to Immune Checkpoint Blockade

Mamatha Serasanambati, Jay Chadokiya, Michitaka Nakano, Maximilian Julve, Pauline Funchain, Saurabh Sharma, Emma Wagner, Prabhjeet Singh, Calvin Jay Kuo, Allison Betof Warner, Amanda Kirane

This study establishes patient-derived melanoma organoids (PDMOs) that retain tumor-immune heterogeneity and show context-dependent responses to immune checkpoint blockade.

bioRxiv · Sep 29, 2026 · PreprintImmunology

XPC loss-of-function triggers melanomagenesis through CDKN2A downregulation

Vipin Shankar Chelakkot, Kiara Thomas, Todd Romigh, Alexis Bernat, Reina Samuel, Nihit Goli, Pooja H. Rambhia, Sairekha Ravichandran, Qi‐En Wang, Kevin D. Cooper, Pauline Funchain, Ying Ni, Joshua Arbesman

This study identifies an XPC variant that promotes melanomagenesis by downregulating CDKN2A through promoter binding, independent of its nucleotide excision repair function.

bioRxiv · Apr 3, 2025 · PreprintCancer Biology