Author

Alasdair MacKenzie

University of AberdeenORCID 0000-0002-7185-229XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Research Focus:gene regulatory network inference· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Organism:human· 3 Approach:statistical model· 3 Assay:DNA methylation· 2 Approach:experimental assay· 2

Frequent Co-Authors

Andrew R. McEwaniD· 5 shared Chris MurgatroydiD· 3 shared Johanna Celene Erickson· 3 shared Mirela DelibegovićiD· 3 shared Connor Davidson· 2 shared Dana Wilson· 2 shared Elizabeth A. Hay· 2 shared Greg Hutchings· 2 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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5 shared papersGenetics

Andrew R. McEwanORCID

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5 papers

Recent·Most cited

Molecular BiologybioRxivPreprintSep 14, 2026

The obesity associated BDNF intron-3 cis-regulatory element, BE5.1, modulates the effects of early-life stress on weight gain, anxiety and gene expression in a sex dependent manner.

Andrew R. McEwan, Joseph Morgan, Greg Hutchings…·Alasdair MacKenzie

The paper investigates how the BDNF intron-3 cis-regulatory element BE5.1 influences the effects of early-life stress on weight gain, anxiety, and gene expression, showing sex-dependent differences.

DOI 10.64898/2026.09.10.750405

mousebulk RNA-seq

𝕏 PostBluesky

GeneticsMolecular PsychiatryPeer-reviewedJan 16, 2024

An ancient polymorphic regulatory region within the BDNF gene associated with obesity modulates anxiety-like behaviour in mice and humans.

Andrew R. McEwan, Benjamin Wen Qing Hing, Johanna Celene Erickson…·Alasdair MacKenzie

The paper investigates a polymorphic regulatory region in the BDNF gene associated with obesity and anxiety in mice and humans, showing altered behavior and gene expression.

6 citations

mousehuman

𝕏 PostBluesky

GeneticsCellular and Molecular Life SciencesPeer-reviewedDec 12, 2020

The anxiety and ethanol intake controlling GAL5.1 enhancer is epigenetically modulated by, and controls preference for, high fat diet

Andrew R. McEwan, Johanna Celene Erickson, Connor Davidson…·Alasdair MacKenzie

The paper investigates how maternal high-fat diet modulates DNA methylation in the GAL5.1 enhancer, affecting offspring's high-fat diet intake and anxiety-related behaviors.

6 citations

mouseDNA methylation

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GeneticsMolecular PsychiatryPeer-reviewedMar 13, 2020

CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake.

Andrew R. McEwan, Connor Davidson, Elizabeth A. Hay…·Alasdair MacKenzie

The paper identifies a conserved enhancer variant in the GAL gene associated with male anxiety and ethanol intake using human data and CRISPR mouse models.

9 citations

humanmouse

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GeneticsbioRxivPreprintMar 5, 2019

Genetic, epigenetic and pharmacological influences modulating tissue specific regulation of the cannabinoid receptor -1 (CB1) gene; implications for cannabinoid pharmacogenetics.

Elizabeth A. Hay, Philip Cowie, Andrew R. McEwan…·Alasdair MacKenzie

The paper investigates genetic and epigenetic factors influencing CB1 gene regulation and their impact on cannabinoid pharmacogenetics through cell-specific functional studies.

3 citations

humanDNA methylation

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