CRISPR disruption and UK Biobank analysis of a highly conserved polymorphic enhancer suggests a role in male anxiety and ethanol intake.
Andrew R. McEwan, Connor Davidson, Elizabeth A. Hay, Yvonne D. Turnbull, Johanna Celene Erickson, Pietro Marini, Dana Wilson, Andrew Mark McIntosh, Mark J. Adams, Chris Murgatroyd, Perry Barrett, Mirela Delibegović, Toni‐Kim Clarke, Alasdair MacKenzie
The paper identifies a conserved enhancer variant in the GAL gene associated with male anxiety and ethanol intake using human data and CRISPR mouse models.
Molecular Psychiatry · Mar 13, 2020Peer-reviewedGenetics