Author

Srikanth R. Polusani

The University of Texas at San Antonio Health Science CenterORCID 0000-0002-7186-0345Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:C. elegans· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexandra TypouiD· 1 shared Arnaud MonteiliD· 1 shared Brandon B. HolmesiD· 1 shared Daohong ZhouiD· 1 shared Donard S. DwyeriD· 1 shared Jeremy A. TanneriD· 1 shared Nattaya ThongsepeeiD· 1 shared Nicholas A. ClantoniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperNeuroscience

Alexandra TypouORCID

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

An AI-Enabled Translational Drug Discovery Framework for NALCN Channelopathy: From High-Throughput Screening to Therapeutic Candidate

Nattaya Thongsepee, Jeremy A. Tanner, Srikanth R. Polusani, Alexandra Typou, Nicholas A. Clanton, Brandon B. Holmes, Philippe Lory, Donard S. Dwyer, Daohong Zhou, Arnaud Monteil, Yaxia Yuan

This paper develops an AI-driven drug discovery framework for NALCN channelopathy, identifying aprepitant as a lead therapeutic candidate through HTS, structural modeling, and experimental validation.

bioRxiv · Oct 9, 2026 · PreprintNeuroscience