Chao‐Ping Hsu

The paper reevaluates transcriptional regulation models by showing that broad data coverage reveals a peaked tradeoff between basal promoter strength and fold change, contradicting previous inverse scaling claims.

The paper introduces BioSANS, a Python-based systems biology software that supports symbolic, deterministic, and stochastic modeling, parameter estimation, and SBML compliance.

This study uses mathematical models to show that coupling transcriptional and post-translational controls via feed-forward loops improves circadian oscillator robustness against basal leakage.