Hsin-Hung David Chou

GBactPro improves cross-species bacterial promoter prediction using element-resolved promoter definitions, achieving high AUROC across multiple species and outperforming existing predictors.

The paper reevaluates transcriptional regulation models by showing that broad data coverage reveals a peaked tradeoff between basal promoter strength and fold change, contradicting previous inverse scaling claims.

The paper investigates the roles of core promoter elements -35 and -10 in Escherichia coli, showing -10 is essential for promoter evolution while -35 influences gene regulation through interactions with transcription factors.

The paper identifies a conserved 3-bp promoter element and reveals regulatory divergence in bacterial promoters between Terrabacteria and Gracilicutes.