Lori A. Pile

SIN3 Regulates Transcriptional and Longevity Responses to Glycolytic Perturbation in Drosophila melanogaster

This study shows SIN3 regulates glycolytic gene expression and lifespan in Drosophila under metabolic stress, acting as a metabolic sensor and linking transcription to organismal adaptation.

The histone modification regulator, SIN3, plays a role in the cellular response to changes in glycolytic flux

This study shows SIN3 regulates metabolic gene expression and influences cellular response to changes in glycolytic flux and mitochondrial stress.

SIN3 gene regulatory activity is linked to RNA polymerase II pausing

The paper analyzes SIN3 isoform regulation of chromatin and gene activity, finding differences in histone methylation and RNA polymerase II pausing between repressed and activated genes.

Isoforms of the transcriptional cofactor SIN3 differentially regulate genes necessary for energy metabolism and cell survival

This study shows that SIN3 isoforms differentially regulate genes involved in energy metabolism and cell survival, with SIN3 187 uniquely affecting mitochondrial function and apoptosis.