Miriam L. Greenberg

TAFAZZIN-knockout C2C12 myoblasts show elevated proline catabolism into the TCA cycle alongside reduced collagen content, proline hydroxylation, crosslinking enzyme LOX, and proline incorporation into ECM proteins.

This study shows SIN3 regulates metabolic gene expression and influences cellular response to changes in glycolytic flux and mitochondrial stress.

The paper shows Scd6 and Edc3 redundantly work with Dhh1 to repress mRNA decay of starvation-induced pathways in yeast.

This study identifies the upregulation of the AMPK-FOXO1-PDK4 pathway as the mechanism causing reduced PDH activity and increased glucose uptake in tafazzin-deficient cells.

This study shows that Dcp2 regulates mRNA abundance and translation to adjust metabolism and filamentation in response to nutrient availability in yeast.

This study shows that SIN3 isoforms differentially regulate genes involved in energy metabolism and cell survival, with SIN3 187 uniquely affecting mitochondrial function and apoptosis.

This study shows that phosphatidic acid (PA) inhibits inositol synthesis by promoting nuclear translocation of IP6K1 and reducing MIPS expression through the AMPK-PLD pathway.