Author

Mark B. De Los Santos

Columbia University Irving Medical CenterORCID 0000-0002-7195-5141Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Approach:experimental assay· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1

Frequent Co-Authors

Adrien T. StanleyiD· 1 shared Aidan C. DalyiD· 1 shared Benjamin D. HobsoniD· 1 shared Bruce CulbertsoniD· 1 shared Christopher A. JacksoniD· 1 shared Colin SmithiD· 1 shared Courteney MattisoniD· 1 shared David L. SulzeriD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperNeuroscience

Adrien T. StanleyORCID

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2 papers

Recent·Most cited

GenomicsbioRxivPreprintOct 23, 2026

Dissecting cellular and molecular networks of aging and senescence in the human hippocampus

Mark B. De Los Santos, Sara Fernández‐García, Kyle Brandon…·Hemali P. Phatnani

This study identifies spatially resolved aging and senescence signatures in the human hippocampus using multi-omics approaches, revealing cell-type and sex-specific gene expression changes.

DOI 10.64898/2026.10.23.761418

humanspatial transcriptomics

𝕏 PostBluesky

NeuroscienceBrain Behavior and ImmunityPeer-reviewedApr 24, 2023

Conserved and cell type-specific transcriptional responses to IFN-γ in the ventral midbrain

Benjamin D. Hobson, Adrien T. Stanley, Mark B. De Los Santos…·David L. Sulzer

The paper shows IFN-γ induces MHC-I expression in ventral midbrain neurons and glia, but with lower amplitude in neurons, and MHC-II is restricted to microglia.

28 citations

mousebulk RNA-seq

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