Author

Benjamin D. Hobson

Columbia University Irving Medical CenterORCID 0000-0002-2745-5318Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:Ribo-seq· 2 Assay:bulk RNA-seq· 1 Assay:proteomics· 1

Frequent Co-Authors

David L. SulzeriD· 4 shared Peter A. SimsiD· 4 shared Eugene V. MosharoviD· 2 shared Adrien T. StanleyiD· 1 shared Bruce CulbertsoniD· 1 shared Étienne HerzogiD· 1 shared Eugene V Mosharov· 1 shared Guomei TangiD· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersNeuroscience

David L. SulzerORCID

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4 papers

Recent·Most cited

NeuroscienceBrain Behavior and ImmunityPeer-reviewedApr 24, 2023

Conserved and cell type-specific transcriptional responses to IFN-γ in the ventral midbrain

Benjamin D. Hobson, Adrien T. Stanley, Mark B. De Los Santos…·David L. Sulzer

The paper shows IFN-γ induces MHC-I expression in ventral midbrain neurons and glia, but with lower amplitude in neurons, and MHC-II is restricted to microglia.

28 citations

mousebulk RNA-seq

NeuroscienceeLifePeer-reviewedJan 31, 2022

Subcellular proteomics of dopamine neurons in the mouse brain reveals axonal enrichment of proteins encoded by Parkinson's disease-linked genes

Benjamin D. Hobson, Se Joon Choi, Eugene V Mosharov…·Peter A. Sims

The paper uses subcellular proteomics to show Parkinson's disease-linked genes are enriched in axons of dopaminergic neurons in the mouse brain.

67 citationstop 2%

mouseproteomics

NeuroscienceCell ReportsPeer-reviewedJan 1, 2022

Subcellular and regional localization of mRNA translation in midbrain dopamine neurons

Benjamin D. Hobson, Linghao Kong, María Florencia Angelo…·Peter A. Sims

The paper investigates mRNA localization and translation in midbrain dopaminergic neurons, finding no axonal localization but dendritic ribosomes and mRNAs related to dopamine synthesis and release.

49 citationstop 3%

mouseRibo-seq

Molecular BiologyCell ReportsPeer-reviewedMar 1, 2019

Widespread Alterations in Translation Elongation in the Brain of Juvenile Fmr1 Knock-Out Mice

Sohani Das Sharma, Jordan B. Metz, Hongyu Li…·Peter A. Sims

This study uses ribosome profiling to show that Fmr1 loss in mice affects translation elongation and initiation, with reduced pausing and altered mRNA binding.

75 citationstop 2%

mouseRibo-seq