Author

David Semela

Kantonsspital St. GallenORCID 0000-0002-7201-743XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:flow cytometry· 1 Assay:imaging· 1

Frequent Co-Authors

Anne GengiD· 2 shared Christine BernsmeieriD· 2 shared Emilio FlintiD· 2 shared Julien RouxiD· 2 shared Markus Hermann HeimiD· 2 shared Matthias Sebastian MatteriD· 2 shared Oltin T. PopiD· 2 shared Robert G. BrenigiD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersImmunology

Anne GengORCID

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2 papers

Recent·Most cited

ImmunologyJournal of HepatologyPeer-reviewedJan 14, 2025

Distinct circulating monocytes up-regulate CD52 and sustain innate immune function in patients with cirrhosis unless acute decompensation emerges

Anne Geng, Robert G. Brenig, Julien Roux…·Christine Bernsmeier

The paper identifies CD52-expressing monocytes in cirrhosis that enhance innate immunity, but their loss during acute decompensation correlates with infection and poor outcomes.

18 citationstop 2%

humanscRNA-seq

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ImmunologybioRxivPreprintMar 29, 2024

Targeting the expansion of myeloid-derived suppressor cells in liver cirrhosis

Emilio Flint, Caner Ercan, Eoin Mitchell…·Christine Bernsmeier

This study investigates MDSC expansion in cirrhosis patients and murine models, showing poly(I:C) reduces MDSC and fibrosis in infected fibrotic mice.

1 citation

humanmouse

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