Matthias Sebastian Matter

Coordinated immune-epithelial dynamics in the nasal epithelium protect against respiratory virus infection

The paper identifies IL13-driven immune-epithelial remodeling in the nasal epithelium that restricts respiratory virus infection by reshaping the mucus barrier.

Longitudinal profiling of tumor-reactive T cells during TIL therapy in metastatic melanoma

This study profiles tumor-reactive T cell dynamics during TIL therapy in metastatic melanoma, identifying factors associated with response and resistance.

Targeting cancer-associated glycosylation for adoptive T cell therapy of gastro-intestinal and gynecological cancers

This study develops a fully human CAR-T cell therapy targeting the STn antigen, showing activity in preclinical models of gastro-intestinal and gynecological cancers.

Distinct circulating monocytes up-regulate CD52 and sustain innate immune function in patients with cirrhosis unless acute decompensation emerges

The paper identifies CD52-expressing monocytes in cirrhosis that enhance innate immunity, but their loss during acute decompensation correlates with infection and poor outcomes.

Targeting the expansion of myeloid-derived suppressor cells in liver cirrhosis

This study investigates MDSC expansion in cirrhosis patients and murine models, showing poly(I:C) reduces MDSC and fibrosis in infected fibrotic mice.

Robust Single-cell Matching and Multi-modalAnalysis Using Shared and Distinct FeaturesReveals Orchestrated Immune Responses

The paper introduces MARIO, a cell matching algorithm that integrates single-cell proteomic and multi-modal data, revealing orchestrated immune responses in lung tissue.