Intranasal parainfluenza virus-vectored vaccine expressing SARS-CoV-2 spike protein of Delta or Omicron B.1.1.529 induces mucosal and systemic immunity and protects hamsters against homologous and heterologous challenge
Hong-Su Park, Yumiko Matsuoka, Celia P. Santos, Cindy Luongo, Xueqiao Liu, Lijuan Yang, Jaclyn A. Kaiser, Eleanor F Duncan, Reed F. Johnson, I‐Ting Teng, Peter D. Kwong, Ursula J. Buchholz, Cyril Le Nouën
This study evaluates intranasal B/HPIV3 vaccines expressing SARS-CoV-2 spike proteins of different variants, showing they induce mucosal and systemic immunity and protect hamsters against homologous and heterologous challenges.
PLoS Pathogens · Apr 21, 2025Peer-reviewedMicrobiology