Deficiency of the RNA-binding protein Cth2 extends yeast replicative lifespan by alleviating its repressive effects on mitochondrial function
Praveen K. Patnaik, Carine Beaupère, Hanna Barlit, Antonia María Romero, Mitsuhiro Tsuchiya, Michael Muir, María Teresa Martínez‐Pastor, Sergi Puig, Matt R. Kaeberlein, Vyacheslav M. Labunskyy
The paper shows that reducing Cth2 activity in yeast increases lifespan by improving mitochondrial function through reduced repression of iron-related genes.
Cell Reports · Jul 1, 2022Peer-reviewedGenomics