NeurosciencebioRxivPreprint
ADAM10- and presenilin 1/γ-secretase-dependent cleavage of PTPRT mitigates neurodegeneration of Alzheimer's disease
Siling Liu, Zhongyu Zhang, Lianwei Li…·Jiali Li
The paper identifies that cleavage of PTPRT by ADAM10 and presenilin 1/γ-secretase produces PICD, which reduces neurodegeneration in Alzheimer's disease by modulating STAT3 and Aβ.