Single-Cell RNA and ATAC Sequencing Reveal Cellular Heterogeneity and Chromatin Accessibility Dynamics in Young Chinese Breast Cancer Patients across Pre- and Post-Neoadjuvant Therapy
Xue Mei Han, Bin Wang, Wenting Xiang, Fan Yu Lin, Bo Sun, Beibei Yang, Zhihan Ruan, Shasha Liu, Shuo Li, Hong Shu Liu, Jian Liu
This study uses scRNA-seq and scATAC-seq to analyze cellular heterogeneity and chromatin accessibility changes in young breast cancer patients before and after neoadjuvant therapy, identifying therapy-resistant genes and signaling pathways.
bioRxiv · Oct 14, 2025 · PreprintCancer Biology