Author

Hong Shu Liu

Tianjin Medical University Cancer Institute and HospitalORCID 0000-0003-3685-6268Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Organism:human· 2 Assay:scATAC-seq· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Jian LiuiD· 2 shared Wenting XiangiD· 2 shared Xue Mei HaniD· 2 shared Zhihan RuaniD· 2 shared Beibei YangiD· 1 shared Bin WangiD· 1 shared Bo SuniD· 1 shared Chang‐Qiang Ke· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersCancer Biology

Jian LiuORCID

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Author profile →

3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintOct 16, 2025

Atlas of Breast Cancer in Chinese Young Women Revealed by Single-cell RNA and ATAC Sequencing

Zhihan Ruan, Linwei Li, Wenting Xiang…·Hong Shu Liu

The paper establishes a single-cell atlas of breast cancer in young Chinese women, identifies new subtypes and therapeutic targets, and reveals distinct tumor progression patterns.

DOI 10.1101/2025.10.16.682857

humanscRNA-seq

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Cancer BiologybioRxivPreprintOct 14, 2025

Single-Cell RNA and ATAC Sequencing Reveal Cellular Heterogeneity and Chromatin Accessibility Dynamics in Young Chinese Breast Cancer Patients across Pre- and Post-Neoadjuvant Therapy

Xue Mei Han, Bin Wang, Wenting Xiang…·Jian Liu

This study uses scRNA-seq and scATAC-seq to analyze cellular heterogeneity and chromatin accessibility changes in young breast cancer patients before and after neoadjuvant therapy, identifying therapy-resistant genes and signaling pathways.

DOI 10.1101/2025.10.14.682233

humanscRNA-seq

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Molecular BiologybioRxivPreprintApr 13, 2020

✦ In-depth digest

Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease in vitro

Haixia Su, Sheng Yao, Wenfeng Zhao…·Yechun Xu

Baicalin and baicalein from Scutellaria baicalensis inhibit SARS-CoV-2 3CL protease non-covalently; a 2.2 Å baicalein complex structure shows an unusual shield-like binding mode.

143 citations

virusprotein structure

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