James Attwater

A polymerase ribozyme that can synthesize both itself and its complementary strand

The paper describes a ribozyme that can synthesize both itself and its complementary strand, suggesting polymerase ribozymes may be more common in RNA sequence space.

5' RNA Aminoacylation via Interstrand Acyl-Transfer

This paper describes a catalytic RNA-based aminoacylation reaction that forms a more stable 5'-aminoacyl RNA linkage, potentially enabling prebiotic RNA-directed peptide synthesis.

Trinucleotide building blocks enable exponential ribozyme-catalysed RNA replication and open-ended growth of diverse RNA sequence pools

RNA trinucleotide substrates and physicochemical cycles enable RNA-catalysed replication of double-stranded RNA and partial self-replication of an RNA polymerase ribozyme.