Edoardo Gianni

The paper describes a ribozyme that can synthesize both itself and its complementary strand, suggesting polymerase ribozymes may be more common in RNA sequence space.

This paper introduces gRNAde, an RNA language model for inverse design of RNA structure and function, achieving success rates comparable to human experts in designing pseudoknotted RNAs.

RNA trinucleotide substrates and physicochemical cycles enable RNA-catalysed replication of double-stranded RNA and partial self-replication of an RNA polymerase ribozyme.