Xiaoyi Gao

This study uses whole-genome sequencing of 488,888 individuals to identify rare genetic variants and novel genes associated with glaucoma, including potential drug targets.

This paper develops a multi-trait polygenic risk score framework to improve POAG prediction across ancestries by integrating glaucoma endophenotypes.

The paper conducts a large exome-wide association study using AD-by-proxy to identify 38 novel genes associated with Alzheimer's disease and related dementias, including potential drug targets.

This study identifies novel genetic loci for BMI, height, and WHRadjBMI in Hispanic/Latino populations and shows the benefits of ancestral diversity in GWAS.

The paper introduces an optimal weighted combination test for detecting novel disease-associated genes using GWAS summary data and shows it outperforms existing methods in simulations and real data.

This paper develops new statistical methods to test gene-environment interactions for multiple traits in sequencing association studies, showing improved power over existing methods.

The paper identifies differentially expressed coding and long noncoding RNAs in keratoconus-affected corneas and finds enriched pathways and correlations suggesting their functional roles.