Krishnakumar Kizhatil

The paper uses single-cell RNA sequencing to identify age-related immune remodeling in ocular outflow tissues that may help maintain intraocular pressure.

The paper uses single-cell transcriptomics to characterize anterior segment development, identifying cell types, pathways, and signaling networks in trabecular meshwork and Schlemm's canal formation.

This study uses whole-genome sequencing of 488,888 individuals to identify rare genetic variants and novel genes associated with glaucoma, including potential drug targets.

The paper performs transcriptomic analyses of Schlemm's canal endothelial cells to reveal their lymphatic identity, three major cell states, and interactions with trabecular meshwork cells.

This study shows GLIS1 regulates trabecular meshwork function and intraocular pressure, with a human variant linked to glaucoma.

This study shows that genetic background affects the severity of glaucoma-related phenotypes in Lmx1b mutant mice, identifies a modifier locus on Chromosome 18, and provides strains with varying phenotypes.