Author

William Lucien Irving

Nottingham University Hospitals NHS TrustORCID 0000-0002-7268-3168Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Genomics· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:gene regulatory network inference· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:GWAS / association mapping· 2 Research Focus:variant effect prediction· 2 Approach:benchmark study· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Eleanor J. BarnesiD· 3 shared John McLauchlaniD· 3 shared M. Azim AnsariiD· 3 shared Graham CookeiD· 2 shared Paul KlenermaniD· 2 shared Peter Simmonds KiD· 2 shared Vincent PedergnanaiD· 2 shared Amy TrebesiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenomics

Eleanor J. BarnesORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintOct 12, 2025

Genome-wide association and gene-virus interaction study of liver disease in hepatitis C virus-infected patients

Jocelyn Quistrebert, Haiting Chai, Yan Chen…·M. Azim Ansari

This study identifies genetic risk factors and host-viral interactions for cirrhosis progression in hepatitis C virus-infected patients but finds no genome-wide significant associations for hepatocellular carcinoma.

DOI 10.1101/2025.10.12.25337816

humanwhole-exome sequencing

𝕏 PostBluesky

GenomicsRNAPeer-reviewedAug 3, 2020

Impact of virus subtype and host IFNL4 genotype on large-scale RNA structure formation in the genome of hepatitis C virus

Peter Simmonds K, Lize Cuypers, William Lucien Irving…·M. Azim Ansari

The paper examines how HCV virus subtype and host IFNL4 genotype influence genome-scale RNA structure formation and compositional features in HCV.

7 citations

humanlong-read sequencing

𝕏 PostBluesky

GenomicsbioRxivPreprintApr 20, 2018

Interferon lambda 4 impacts broadly on hepatitis C virus diversity.

M. Azim Ansari, Elihú Aranday-Cortés, Camilla L. C. Ip…·Vincent Pedergnana

The paper examines the impact of IFN-lambda4 on HCV diversity using host and viral genetic data from 485 patients, finding that IFN-lambda4 variants influence viral amino acid diversity and load.

DOI 10.1101/305151

humanDNA methylation

𝕏 PostBluesky