Eleanor J. Barnes

Genome-wide association and gene-virus interaction study of liver disease in hepatitis C virus-infected patients

This study identifies genetic risk factors and host-viral interactions for cirrhosis progression in hepatitis C virus-infected patients but finds no genome-wide significant associations for hepatocellular carcinoma.

Human tonsil organoids reveal innate pathways modulating humoral and cellular responses to ChAdOx1

This study uses human tonsil organoids to investigate innate pathways regulating humoral and cellular responses to ChAdOx1, identifying key roles for IFN- and IL-6.

Lineage-aware evolutionary analysis of hepatitis C virus within-host dynamics

This study analyzes HCV within-host dynamics post-DAA treatment failure, finding persistent viral subpopulations and lineage-specific evolutionary rates.

Pan-genotypic probe-based enrichment to improve efficiency of Hepatitis B virus sequencing

This paper introduces a pan-genotypic probe-based enrichment method to enhance HBV sequencing efficiency, showing significant increases in HBV read counts and viral load correlation.

Impact of virus subtype and host IFNL4 genotype on large-scale RNA structure formation in the genome of hepatitis C virus

The paper examines how HCV virus subtype and host IFNL4 genotype influence genome-scale RNA structure formation and compositional features in HCV.

Illumina and Nanopore methods for whole genome sequencing of hepatitis B virus (HBV)

This paper describes a method to generate full-length HBV genome data using isothermal amplification and sequencing with Nanopore and Illumina, achieving high consensus accuracy and resolving intra-sample variants.

A comprehensive genomics solution for HIV surveillance and clinical monitoring in a global health setting

This paper introduces veSEQ-HIV, a cost-effective, high-throughput sequencing method for HIV that recovers complete genomes and quantifies viral load, enabling drug resistance monitoring and transmission analysis.

Interferon lambda 4 impacts broadly on hepatitis C virus diversity.

The paper examines the impact of IFN-lambda4 on HCV diversity using host and viral genetic data from 485 patients, finding that IFN-lambda4 variants influence viral amino acid diversity and load.