Mycobacterial Phenolic Glycolipid Triggers ATP-Mediated Neuronal P2X3 Signaling and Cough
Kubra Fatima Naqvi, Lois L. Warden, Jan Dijk, Dhananjay K. Naik, Felipe Espinosa-Becerra, Ifunanya M. Okolie, Vincent V. F. Verhoeks, Kathryn C. Rahlwes, Christopher P. Xavier, Jeroen D. C. Codée, Theodore John Price, Michael U. Shiloh
This study shows that Mycobacterium tuberculosis produces phenolic glycolipid (PGL) that activates neurons and induces cough by triggering ATP-mediated P2X3 signaling.
bioRxiv · May 1, 2025 · PreprintNeuroscience