Michael U. Shiloh

This study shows SMURF2 inhibits autophagy against Mycobacterium tuberculosis in macrophages, suggesting it as a potential target for tuberculosis therapy.

This study generates a Pglyrp1-Cre mouse to target M cells and related lineages in mucosal tissues, showing tissue-specific promoter activity and challenges in achieving M cell-specific targeting.

This study identifies CMPK2 as a host factor that restricts Mycobacterium tuberculosis replication in human macrophages and alters gene expression related to innate immunity.

This study identifies SNX5 as a regulator of MHC-II antigen presentation during Mtb infection, linking endosomal sorting to immune responses against intracellular pathogens.

The paper identifies host proteins regulating Mycobacterium tuberculosis replication in macrophages using cysteine reactivity profiling and genetic perturbation.

This study shows that airflow constraints can suppress tuberculosis transmission in guinea pigs, even under conditions that would otherwise allow transmission.

This study identifies USP15 as a negative regulator of autophagy and macrophage immunity to Mycobacterium tuberculosis, showing that its inhibition reduces bacterial burden.

This study uses snRNA-seq to identify molecular features of human airway microfold cells and discovers a novel epithelial cell type with an interferon-stimulated gene signature.

This study develops a humanized lung-on-a-chip model to study early immune responses to Mycobacterium fortuitum infection, revealing cytokine and protease inhibitor upregulation.

This study shows that Mycobacterium tuberculosis sulfolipid-1 (SL-1) increases TRPV1-positive sensory neuron excitability through Gq/11 pathway activation and intracellular Ca2+ release.

This study shows that Mycobacterium tuberculosis produces phenolic glycolipid (PGL) that activates neurons and induces cough by triggering ATP-mediated P2X3 signaling.

The paper develops a method to image phenolic glycolipid (PGL) in mycobacteria using bioorthogonal metabolic labeling and demonstrates its application in studying PGL dynamics.

The paper identifies Mpt64 as a M. tuberculosis secreted protein that binds eukaryotic membranes and is necessary for bacterial survival in macrophages.