Kathryn C. Rahlwes

SMURF2 inhibits autophagic control of Mycobacterium tuberculosis in macrophages

This study shows SMURF2 inhibits autophagy against Mycobacterium tuberculosis in macrophages, suggesting it as a potential target for tuberculosis therapy.

CMPK2 restricts Mycobacterium tuberculosis replication and regulates macrophage gene expression

This study identifies CMPK2 as a host factor that restricts Mycobacterium tuberculosis replication in human macrophages and alters gene expression related to innate immunity.

Sorting nexin 5 mediates antigen presentation and immunity against Mycobacterium tuberculosis

This study identifies SNX5 as a regulator of MHC-II antigen presentation during Mtb infection, linking endosomal sorting to immune responses against intracellular pathogens.

Deubiquitinase USP15 restricts autophagy and macrophage immunity to Mycobacterium tuberculosis

This study identifies USP15 as a negative regulator of autophagy and macrophage immunity to Mycobacterium tuberculosis, showing that its inhibition reduces bacterial burden.

Mycobacterial Phenolic Glycolipid Triggers ATP-Mediated Neuronal P2X3 Signaling and Cough

This study shows that Mycobacterium tuberculosis produces phenolic glycolipid (PGL) that activates neurons and induces cough by triggering ATP-mediated P2X3 signaling.