Chaoyang Wang

Evidence Scaling for Zero-Shot Protein Reasoning with Large Language Models

This paper shows that adding biological evidence to large language models improves zero-shot protein variant prediction without retraining the model.

MuseDrift: Navigating Protein Evolutionary Manifolds with Conditional Discrete Diffusion

MuseDrift generates protein variants with specified sequence identity to a wild-type sequence, achieving higher structural prediction confidence and better mutation-effect scores than existing methods.

Vulnerability in the breadth evolution of an influenza broadly neutralizing antibody

This study investigates the constraints on the breadth evolution of the CR9114 broadly neutralizing antibody by comparing binding affinity landscapes across different influenza HA subtypes.