Qi Wen Teo

This study quantifies the replication fitness effects of mutations in diverse H1N1 influenza neuraminidases, revealing strain-dependent effects and epistasis patterns.

The paper shows that single-cell heterogeneity in IFN induction potential is heritable and driven by baseline variation in JNK and AP-1 signaling states.

This study identifies UCHL3 as a host factor that stabilizes subgenomic flaviviral RNA condensates, promoting virus replication through interferon-independent mechanisms.

This study identifies a cross-reactive germline antibody that can be evolved to neutralize multiple SARS-CoV-2 variants through targeted somatic mutations.

This study shows TRIM21 acts as a molecular rheostat regulating influenza A virus replication by modulating ubiquitination and innate immune signaling, with PRKDC as a compensatory antiviral factor when TRIM21 is absent.

This study characterizes antibody responses to H3 influenza A virus in mallard ducks, revealing unique features compared to human antibodies and highlighting gene conversion in antibody evolution.

This study shows that antibodies against influenza virus neutralize by interacting with the viral membrane, and disrupting these interactions reduces their effectiveness.

This study characterizes two non-competing group 2 influenza HA stem antibodies and shows their in vivo protective efficacy despite limited in vitro neutralization.

This study identifies three IGHV3-23 antibodies targeting influenza HA stem, showing that non-neutralizing antibodies with enhanced Fc-mediated effector functions offer better in vivo protection than a potent neutralizer.

This study investigates the constraints on the breadth evolution of the CR9114 broadly neutralizing antibody by comparing binding affinity landscapes across different influenza HA subtypes.

This study identifies an antibody that cross-reacts with H5N1 and H3N2 neuraminidases and shows how somatic hypermutation enables this cross-reactivity.

The paper identifies intrinsic OASL expression as a determinant of IFN induction potential in influenza A virus-infected cells using scRNA-seq analysis.

This study uses deep mutational scanning to analyze the functional impact of NEP mutations in influenza A virus, revealing pleiotropic effects on viral replication and host adaptation.

This study compares the ability of seasonal H1N1 and H3N2 influenza A viruses to antagonize interferon induction and signaling at the single-cell level, finding differences in their IFN antagonism potential.

This study examines how immune history affects antibody responses to influenza H1N1 hemagglutinin and neuraminidase in mice, finding that HA responses are more restricted by prior infection than NA responses.

This study identifies sequence constraints for IGHV1-69 antibodies targeting influenza HA stem, showing light chain and CDR H3 sequences coordinate HA stem specificity.