Targeting CXCR4 with -Pentixather Significantly Increases Overall Survival in Small Cell Lung Cancer
Keegan A. Christensen, Melissa A. Fath, Jordan T. Ewald, Claudia Robles-Planells, Stephen A. Graves, Spenser S. Johnson, Zeb Ralph Zacharias, Jon C. D. Houtman, Mary Sue O'Dorisio, Michael K. Schultz, Bryan G. Allen, Muhammad Furqan, Yusuf Menda, Dijie Liu, Douglas R. Spitz
This study shows that [212Pb/203Pb]-pentixather targeting CXCR4 improves survival in SCLC xenografts and causes temporary bone marrow cytopenias that resolve.
Radiation Research · Jul 3, 2025Peer-reviewedCancer Biology