Author

Jon C. D. Houtman

University of IowaORCID 0000-0002-5307-9854Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Alexander W. BoydeniD· 1 shared Ali JabbariiD· 1 shared Benjamin W. DarbroiD· 1 shared Bryan G. AlleniD· 1 shared Chaitanya RastogiiD· 1 shared Chantal AllamargotiD· 1 shared Claudia Robles-PlanellsiD· 1 shared Connor R. WilhelmiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperCancer Biology

Alexander W. BoydenORCID

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Author profile →

3 papers

Recent·Most cited

Intratumoral plasma cells are required for activation of CD8+ T cells and success of immune checkpoint blockade therapy in de novo MPNSTs

Joshua J. Lingo, Ryan J. Reis, Chantal Allamargot, Juan A. Raygoza Garay, Courtney A. Kaemmer, Elizabeth C. Elias, Ellen M. Voigt, Ali Jabbari, Connor R. Wilhelm, Alexander W. Boyden, Nitin J. Karandikar, Patrick John Breheny, David Kyle Meyerholz, Rebecca D. Dodd, Jon C. D. Houtman, , Dawn E. Quelle

This study shows that intratumoral plasma cells are essential for CD8+ T cell activation and response to immune checkpoint blockade therapy in MPNSTs.

bioRxiv · Feb 20, 2026 · PreprintCancer Biology

Targeting CXCR4 with -Pentixather Significantly Increases Overall Survival in Small Cell Lung Cancer

Keegan A. Christensen, Melissa A. Fath, Jordan T. Ewald, Claudia Robles-Planells, Stephen A. Graves, Spenser S. Johnson, Zeb Ralph Zacharias, Jon C. D. Houtman, Mary Sue O'Dorisio, Michael K. Schultz, Bryan G. Allen, Muhammad Furqan, Yusuf Menda, Dijie Liu, Douglas R. Spitz

This study shows that [212Pb/203Pb]-pentixather targeting CXCR4 improves survival in SCLC xenografts and causes temporary bone marrow cytopenias that resolve.

Radiation Research · Jul 3, 2025Peer-reviewedCancer Biology

SelexGLM differentiates androgen and glucocorticoid receptor DNA-binding preference over an extended binding site

Liyang Zhang, Gabriella D. Martini, H. Tomas Rube, Judith F. Kribelbauer-Swietek, Chaitanya Rastogi, Vincent FitzPatrick, Jon C. D. Houtman, Harmen J. Bussemaker, Miles A. Pufall

This study identifies differences in DNA-binding preferences between androgen and glucocorticoid receptors using SELEX-seq and SelexGLM, revealing AR's greater sequence sensitivity and enthalpy-driven binding.

Genome Research · Jan 1, 2018Peer-reviewedSystems Biology