Author

Spenser S. Johnson

University of IowaORCID 0009-0008-9770-8924Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Abbey M. SykesiD· 1 shared Bryan G. AlleniD· 1 shared Claudia Robles-PlanellsiD· 1 shared Collin D. HeeriD· 1 shared Dijie LiuiD· 1 shared Douglas R. SpitziD· 1 shared James L. EliaiD· 1 shared Jarvis HilliD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Abbey M. SykesORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJul 9, 2026

Leveraging Homologous Recombination Deficiency via the Repositioned Prodrug CB1954

James L. Elia, Jarvis Hill, Collin D. Heer…·Ranjit S. Bindra

This paper identifies CB1954 as a selective therapy for BRCA2-deficient cancers by showing its activity in HRD cells and mechanism of action.

DOI 10.64898/2026.07.08.737246

humangenetic perturbation / CRISPR

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Cancer BiologyRadiation ResearchPeer-reviewedJul 3, 2025

Targeting CXCR4 with -Pentixather Significantly Increases Overall Survival in Small Cell Lung Cancer

Keegan A. Christensen, Melissa A. Fath, Jordan T. Ewald…·Douglas R. Spitz

This study shows that [212Pb/203Pb]-pentixather targeting CXCR4 improves survival in SCLC xenografts and causes temporary bone marrow cytopenias that resolve.

5 citations

mouseexperimental assay

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