Author

Jonathan K. Williams

Bristol-Myers Squibb (United States)ORCID 0000-0002-7272-6885Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Approach:statistical model· 1 Organism:virus· 1

Frequent Co-Authors

Andrew SamiD· 2 shared Jean BaumiD· 2 shared Aaliyah KhaniD· 1 shared Abdullah Naiyer· 1 shared Alan Trudeau· 1 shared Ali A. KhaniD· 1 shared Allison Rupert· 1 shared Ashish DuvvuruiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersBiophysics

Andrew SamORCID

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2 papers

Recent·Most cited

Is synuclein aggregation a derived or ancestral trait? Ancestral sequence reconstruction uncovers stepwise evolution of synuclein aggregation

Andrew Sam, Seungwoo Lee, Jordan Elliott, Emma Larson, Abdullah Naiyer, Jonathan K. Williams, Jean Baum

This study uses ancestral sequence reconstruction to show that synuclein aggregation evolved progressively, with fibril formation emerging in an ancestral node and being suppressed in beta-synuclein.

bioRxiv · Sep 27, 2025 · PreprintBiophysics

Evolution of the SARS-CoV-2 proteome in three dimensions (3D) during the first six months of the COVID-19 pandemic

Joseph H. Lubin, Christine Zardecki, Elliott M. Dolan, Changpeng Lu, Zhuofan Shen, Shuchismita Dutta, John Westbrook, Brian P. Hudson, David S. Goodsell, Jonathan K. Williams, Maria Voigt, Vidur Sarma, Lingjun Xie, Thejasvi Venkatachalam, Steven Arnold, , Stephen Kevin Burley

The paper analyzes 3D structural changes in SARS-CoV-2 proteins during the first six months of the pandemic, showing amino acid substitutions primarily affect surfaces and boundary layers.

bioRxiv · Dec 1, 2020 · PreprintMolecular Biology