Joseph H. Lubin

This paper shows how HtrA1* inhibits alpha-synuclein aggregation through synergistic interactions with its PDZ and Protease domains.

This paper introduces PGCN, a structure-aware graph convolutional network for predicting protease specificity and designing proteases, showing accurate predictions and successful experimental validation.

The paper analyzes the diversity of coronaviral main protease active sites to identify potential broad-spectrum inhibitors for future pandemics.

The paper analyzes 3D structural changes in SARS-CoV-2 proteins during the first six months of the pandemic, showing amino acid substitutions primarily affect surfaces and boundary layers.