Jean Baum

This study quantifies how α-Synuclein monomers and seeds affect the material properties of Tau condensates, showing distinct effects on viscosity and interfacial tension.

This study shows that fluorescently tagged proteins in biomolecular condensates undergo crosslinking due to excitation-induced ROS, leading to condensate solidification and highlighting redox regulation of condensate properties.

This study uses ancestral sequence reconstruction to show that synuclein aggregation evolved progressively, with fibril formation emerging in an ancestral node and being suppressed in beta-synuclein.

This study examines how collagen mutations affect fibril structure and integrin interactions, showing that different mutations lead to distinct structural and functional changes in collagen.

The paper identifies genes regulating alpha-synuclein homeostasis and shows their differential expression correlates with increased rare risk variant burden in Parkinson's disease.

The paper quantifies viscoelastic properties of synapsin condensates in live cells and identifies α-synuclein's role in regulating their material state.

This paper shows how HtrA1* inhibits alpha-synuclein aggregation through synergistic interactions with its PDZ and Protease domains.

The paper analyzes 3D structural changes in SARS-CoV-2 proteins during the first six months of the pandemic, showing amino acid substitutions primarily affect surfaces and boundary layers.