Suhita Nadkarni

Structural specialization of mossy fiber boutons is necessary for their unique computational functions

The paper develops a computational model of mossy fiber boutons to show that structural features like loose VDCC coupling and large inter-AZ distances are essential for short-term plasticity and pattern separation.

Nanoscale Lattice Organization of Molecular Condensates Drives Compositional Degeneracy in Synaptic Plasticity

This study shows how nanoscale organization of Bassoon and VGCCs in synapses enables functional adaptability through compositional degeneracy and thermodynamic regulation during synaptic plasticity.

Amyloid pathology disrupts gliotransmitter release in astrocytes

This study shows that amyloid-beta pathology increases Ca2+ and exocytotic event synchrony and reduces temporal precision in astrocytes, disrupting gliotransmitter release.

Presynaptic Endoplasmic Reticulum Contributes Crucially to Short-term Plasticity in Small Hippocampal Synapses

The paper investigates the role of presynaptic endoplasmic reticulum in modulating short-term plasticity in hippocampal synapses using computational modeling.

Role of slow temporal dynamics in reliableactivity of stochastically driven neurons

The paper investigates how stochastic noise affects the firing patterns of a neuronal network motif and shows that slow temporal dynamics enhance noise tolerance and rhythmic activity.

Local design principles at hippocampal synapsesrevealed by an energy-information trade-off

The paper investigates how hippocampal synapses balance information transfer and energy use through probabilistic transmitter release and short-term plasticity, revealing design principles that optimize synaptic function.

Biophysical basis of alpha rhythm disruption in Alzheimer’s disease

The paper uses a biophysically detailed model to investigate how reduced HCN channel expression in Alzheimer's disease disrupts alpha rhythms and explores the effects of acetylcholine modulation.

Intracellular calcium stores mediate a synapse-specific form of metaplasticity at hippocampal dendritic spines

The paper investigates how ER-associated calcium stores modulate NMDA receptor-dependent plasticity at hippocampal CA1 synapses, showing ER selectively enhances LTD induction.