Deepak Kumar Nair

SIRT2 attenuates stress-induced skeletal muscle atrophy by inhibiting glucocorticoid receptor signaling

This study identifies SIRT2 as a regulator of stress-induced skeletal muscle atrophy by inhibiting glucocorticoid receptor signaling, showing protective effects in mice.

Palmitoylation of PSD95 flips the bilayer juxtaposed domain and drives cluster formation on membrane

This study reveals how palmitoylation of PSD95 reorients its domains to promote membrane association and clustering, with lipid composition modulating this process.

IntAct-U-ExM: Ultrastructure Expansion microscopy of actin networks via an internally-tagged actin

The paper develops IntAct-U-ExM to visualize actin networks with super-resolution, showing improved resolution of actin structures in yeast and mammalian cells.

Nanoscale Lattice Organization of Molecular Condensates Drives Compositional Degeneracy in Synaptic Plasticity

This study shows how nanoscale organization of Bassoon and VGCCs in synapses enables functional adaptability through compositional degeneracy and thermodynamic regulation during synaptic plasticity.

SRF-deficient astrocytes provide neuroprotection in mouse models of excitotoxicity and neurodegeneration

This study shows that deleting SRF in astrocytes creates neuroprotective astrocytes that reduce neuronal damage in mouse models of excitotoxicity and neurodegenerative diseases.

Golgi Fragmentation - One of the Earliest Organelle Phenotypes in Alzheimer's Disease Neurons

The paper identifies Golgi fragmentation as an early AD phenotype in neurons using stem cell and mouse models, showing its link to SORL1 variants and glycosylation changes.

Function of FMRP domains in regulating distinct roles of neuronal protein synthesis

This study identifies the functional roles of FMRP domains in translation regulation, showing that the C-terminus mediates ribosome binding and repression, while domain synergy is needed for granule formation and microtubule association.

Vinculin mediated axon growth requires interaction with actin but not talin

This study shows that vinculin's tail domain affects neuronal migration and axon growth through actin interactions, independent of talin.

Measuring mRNA translation in neuronal processes and somata by tRNA-FRET

This study visualizes tRNA and protein synthesis in neurons using fluorescent tRNAs, revealing spatial differences in tRNA motion and GluR-dependent translation up-regulation during LTP.