Shekhar Kedia

Nanoscopic tau aggregates in Parkinson's disease

This study uses SiMPull to detect nanoscopic tau aggregates in PD brain regions, finding high-intensity aggregates in some PD cases despite negative IHC results.

Tau aggregate replication occurs at the pre-synapse of cultured human neurons and increases with application of TNFa

The paper shows TNFα promotes tau aggregation at pre-synapses in human neurons, forming non-fibrillar aggregates that replicate rapidly.

Assessing the impact of mono- and bi-allelic deletions in NRXN1 on synaptic function

This study compares mono- and bi-allelic NRXN1 mutations in iPSC-derived neurons, showing bi-allelic mutations cause more severe molecular, synaptic, and functional impairments.

Early synaptic pathology is associated with small tau aggregates in Alzheimer's disease

The paper examines tau aggregates in Alzheimer's disease synaptosomes, finding that small tau aggregates are associated with early synaptic pathology.

Hyaluronidase unlocks sequestered CEACAM5 and improves CAR T-cell therapy in colorectal cancer

This study shows that hyaluronidase improves CEACAM5 accessibility on colorectal cancer cells, enhancing CAR T-cell therapy effectiveness by reducing glycocalyx thickness and restoring sustained T-cell activation.

T-cell signaling relies on partial CD45-exclusion at sub-micron sized cellular contacts

The paper shows that T-cell activation is initiated by partial CD45 exclusion at sub-micron contacts, leading to strong activation and cytotoxicity through small signaling changes.

Nanoscale Lattice Organization of Molecular Condensates Drives Compositional Degeneracy in Synaptic Plasticity

This study shows how nanoscale organization of Bassoon and VGCCs in synapses enables functional adaptability through compositional degeneracy and thermodynamic regulation during synaptic plasticity.

A human neuronal model of sporadic Alzheimer's disease induced by FBXO2 downregulation shows A β aggregation, tau hyperphosphorylation and functional network impairment

This study shows that downregulating FBXO2 in human iPSC-derived neurons leads to Alzheimer's disease-like features including Aβ aggregation and tau hyperphosphorylation.

SynPull: a novel method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy

SynPull combines single-molecule pulldown, super-resolution microscopy, and computational analysis to study protein aggregates in synaptosomes from human and mouse samples, revealing AT8-positive tau as the predominant aggregate in Alzheimer's disease.

Golgi Fragmentation - One of the Earliest Organelle Phenotypes in Alzheimer's Disease Neurons

The paper identifies Golgi fragmentation as an early AD phenotype in neurons using stem cell and mouse models, showing its link to SORL1 variants and glycosylation changes.