Author

Yanmei Lu

Sangamo BioSciences (United States)ORCID 0000-0002-7293-8634Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Organism:non-human primate· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Amy M. PooleriD· 2 shared Bryan ZeitleriD· 2 shared Kathleen E. MeyeriD· 2 shared Mihika Jalan· 2 shared Sarah J. HinkleyiD· 2 shared Toufan Parman· 2 shared Alaric Falcon· 1 shared Alex Michael WardiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersNeuroscience

Amy M. PoolerORCID

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2 papers

Recent·Most cited

Zinc Finger Repressors mediate widespread PRNP lowering in the nonhuman primate brain and profoundly extend survival in prion disease mice

Shih-Wei Chou, Meredith A Mortberg, Kimberly Marlen, David S. Ojala, Toufan Parman, Michael Howard, Kendrick DeSouza-Lenz, Yuan Lian, Mohadeseh Mehrabian, Matthew R. Tiffany, Annemarie Ledeboer, Patrick Dunn, Jing Hu, Kenia Guzman, Nikita Kamath, , Bryan Zeitler

This study demonstrates that Zinc Finger Repressors (ZFRs) reduce prion protein (PrP) expression in nonhuman primates and extend survival in prion disease mice.

bioRxiv · Mar 5, 2025 · PreprintNeuroscience

Potent and selective repression of SCN9A by engineered zinc finger repressors for the treatment of neuropathic pain

Mohammad Samie, Toufan Parman, Mihika Jalan, Jisoo Lee, Patrick J. Dunn, Jason A. Eshleman, Dianna Baldwin Vidales, Josh Holter, Brian Jones, Yonghua Pan, Marina Falaleeva, Sarah J. Hinkley, Alicia Goodwin, Tammy Chen, Sumita Bhardwaj, , Amy M. Pooler

This study demonstrates the use of engineered zinc finger repressors delivered via AAV to reduce SCN9A expression in preclinical models, showing efficacy in reducing neuropathic pain.

bioRxiv · Sep 6, 2024 · PreprintNeuroscience