Author

Matthew R. Tiffany

Denali Therapeutics (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:non-human primate· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Alaric Falcon· 1 shared Alissa A. CoffeyiD· 1 shared Amy M. PooleriD· 1 shared Annemarie Ledeboer· 1 shared Bryan ZeitleriD· 1 shared Chiara MelisiD· 1 shared Daniel W. ChungiD· 1 shared David S. Ojala· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperNeuroscience

Alaric Falcon

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Zinc Finger Repressors mediate widespread PRNP lowering in the nonhuman primate brain and profoundly extend survival in prion disease mice

Shih-Wei Chou, Meredith A Mortberg, Kimberly Marlen, David S. Ojala, Toufan Parman, Michael Howard, Kendrick DeSouza-Lenz, Yuan Lian, Mohadeseh Mehrabian, Matthew R. Tiffany, Annemarie Ledeboer, Patrick Dunn, Jing Hu, Kenia Guzman, Nikita Kamath, , Bryan Zeitler

This study demonstrates that Zinc Finger Repressors (ZFRs) reduce prion protein (PrP) expression in nonhuman primates and extend survival in prion disease mice.

bioRxiv · Mar 5, 2025 · PreprintNeuroscience

Using a bar-coded AAV capsid library to select for novel clinically relevant gene therapy vectors

Katja Pekrun, Gustavo de Alencastro, Qing-Jun Luo, Jun Liu, Young‐Jin Kim, Sean C. Nygaard, Feorillo Galivo, Feijie Zhang, Ren Song, Matthew R. Tiffany, Jianpeng Xu, Matthias Hebrok, Markus Grompe, Mark A. Kay

The paper develops a barcoded AAV capsid library to identify novel gene therapy vectors with improved transduction efficiency in human islets and hepatocytes.

JCI Insight · Nov 13, 2019Peer-reviewedGenetics