Discovery of a novel antibiotic class targeting the enolase of Acinetobacterbaumannii
Irene Molina Panadero, Antonio Moreno Rodríguez, Mercedes de la Cruz, Pilar Sánchez, Laura Tomás Gallardo, Thanadon Samernate, Milan Senćanski, Sanja Glišić, Olga Genilloud, Poochit Nonejuie, Antonio J. Pérez-Pulido, Abdelkrim Hmadcha, Younes Smani
This study identifies ENOblock, an anticancer drug, as a novel antibiotic targeting Acinetobacter baumannii enolase, showing synergy with colistin and efficacy in vivo.
bioRxiv · Apr 23, 2025 · PreprintMicrobiology