Younes Smani

OmpA controls intracellular survival of Acinetobacter baumannii through TFEB activation and lysosomal remodeling

This study identifies an OmpA-iPLA2-LPC-ORAI1-TFEB signaling axis that enables Acinetobacter baumannii to survive intracellularly by modulating lysosomal function and counteracting host defenses.

Innate antiviral systems are major defensome components that drive prophage distribution in Acinetobacter baumannii

The paper analyzes defense systems in Acinetobacter baumannii genomes and finds that innate systems influence prophage distribution and genome evolution.

Antibacterial activity of tamoxifen derivatives against methicillin-resistant Staphylococcus aureus

This study evaluates the antibacterial activity of 22 tamoxifen derivatives against MRSA, finding three derivatives with dose-dependent growth inhibition and increased membrane permeability.

Discovery of a novel antibiotic class targeting the enolase of Acinetobacterbaumannii

This study identifies ENOblock, an anticancer drug, as a novel antibiotic targeting Acinetobacter baumannii enolase, showing synergy with colistin and efficacy in vivo.