Manish Jaiswal

This study identifies CSN7 as essential for Drosophila neuroblast growth and proliferation by regulating the Akt/mTor pathway through Cul1.

This study investigates how Bendless-mediated K63 ubiquitination regulates Drosophila hematopoiesis by modulating Wingless and JNK signaling pathways.

The paper introduces FRAPPe, a FRET-based biosensor for detecting inorganic polyphosphates, which can quantify polyP levels and is useful for high-throughput screens.

This study identifies IP6K1 as a regulator of mitochondrial polyP synthesis and function, showing its role in energy homeostasis through 5-InsP7 production and a catalytic-independent mechanism.

The paper studies mitochondrial morphogenesis during spermiogenesis in Drosophila, showing how coordinated membrane dynamics and vesicle-mediated remodeling drive organelle patterning.

This study identifies DYRK1A's role in promoting mTORC1 activity by inhibiting TSC complex activity through phosphorylation of TSC2, and shows conservation in Drosophila.

The paper shows that the ratio of spitz to argos expression, not absolute levels, determines Drosophila eye patterning through buffered EGFR signaling.

The paper identifies Bendless as a regulator of PINK1-Park activity that controls Mitofusin degradation under mitochondrial stress, with implications for neuroprotection.

The paper introduces two new genetic tools for efficiently tagging genes in Drosophila using MiMIC and CRISPR, enhancing integration efficiency and enabling precise gene manipulation.