Author

Sylvain Tollis

ORCID 0000-0002-7301-4556Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Alexander EhmanniD· 1 shared Andrea HäneliD· 1 shared Aya Abdelsalam· 1 shared Martin JädersteniD· 1 shared Nikolas HeroldiD· 1 shared Rakan NaboulsiiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

6 top collaborators · 7 mutual co-author links

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1 shared paperSystems Biology

Alexander EhmannORCID

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2 papers

Recent·Most cited

Functionalist Oncology to Model the Contextuality of Dynamics and Treatment in Acute Myeloid Leukemia

Alexander Ehmann, Rakan Naboulsi, Martin Jädersten, Sylvain Tollis, Nikolas Herold

This paper introduces a functionalist oncology framework using edge-weighted digraphs to model AML treatment dynamics and evaluate drug combinations, including SAMHD1 inhibitors.

bioRxiv · Dec 23, 2025 · PreprintSystems Biology

Hematopoietic proliferation is orchestrated by the sequential and lineage-specific activation of Cyclin D, Cyclin E and CDKN sub-modules within the G1/S network

Andrea Hänel, Aya Abdelsalam, Sylvain Tollis

The paper uses single cell transcriptomics and mathematical modeling to show how cyclin D, cyclin E, and CDKN sub-modules in the G1/S network drive distinct proliferation trajectories in hematopoietic cells.

bioRxiv · May 15, 2025 · PreprintSystems Biology