This paper introduces a functionalist oncology framework using edge-weighted digraphs to model AML treatment dynamics and evaluate drug combinations, including SAMHD1 inhibitors.

bioRxiv · Dec 23, 2025 · PreprintSystems Biology

An intronic copy number variation in Syntaxin 17 determines speed of greying and melanoma incidence in Grey horses

Carl‐Johan Rubin, McKaela Hodge, Rakan Naboulsi, Madeleine Beckman, Rebecca R. Bellone, Angelica Kallenberg, Stephanie J’Usrey, Hajime Ohmura, Kazuhiro Seki, Aoi Ohnuma, Brian W. Davis, Teruaki Tozaki, Gabriella Lindgren, Leif Andersson

bioRxiv · Nov 5, 2023 · PreprintGenetics

An equine Endothelin 3 cis-regulatory variant links blood pressure modulation to elite racing performance

Kim Fegraeus, Maria Rosengren, Rakan Naboulsi, Ludovic Orlando, Magnus Åbrink, Annika Thorsell, Ahmad Jouni, Brandon D. Velie, Amanda Raine, Beate Egner, C. Mikael Mattsson, Göran Andersson, Jennifer R. S. Meadows, Gabriella Lindgren

This paper identifies a cis-regulatory variant near EDN3 linked to blood pressure regulation and elite racing performance in horses.

bioRxiv · Nov 4, 2022 · PreprintGenetics

Dissection of the cellular function of the ZBED6 transcription factor in mouse myoblast cells using gene editing, RNAseq and proteomics

Shady Younis, Rakan Naboulsi, Xuan Wang, Xiaofang Cao, Mårten Larsson, Ernest Sargsyan, Peter Bergsten, Nils Welsh, Leif Andersson

This study investigates ZBED6's role in mouse myoblasts using gene editing, RNAseq, and proteomics, showing ZBED6 regulates IGF2 through a specific binding site, affecting mitochondrial activity and myogenesis.

bioRxiv · Feb 5, 2019 · PreprintMolecular Biology