Andrea Hänel

This study identifies Treacle and NBS1 as components of TOPBP1 condensates that activate ATM signaling and show their cooperative role in organizing DNA damage responses.

This paper shows CIP2A recruits the SMX tri-nuclease complex to manage under-replicated DNA during mitosis, preventing chromosome segregation errors in HRD cancers.

The paper uses single cell transcriptomics and mathematical modeling to show how cyclin D, cyclin E, and CDKN sub-modules in the G1/S network drive distinct proliferation trajectories in hematopoietic cells.

This study identifies H1-0 as a mediator of ETV6::RUNX1-induced quiescence in BCP-ALL preleukemic cells and suggests HDACi treatment as a potential therapeutic approach.