Sonic hedgehog medulloblastoma cells in co-culture with cerebellar organoids converge towards in vivo malignant cell states
Max J. van Essen, Alina Nicheperovich, Benjamin Schuster‐Böckler, Esther B. E. Becker, John Jacob
This study shows SHH-MB cells in co-culture with cerebellar organoids adopt patient tumor-like phenotypes and heterogeneity, suggesting microenvironment-driven malignant states.
Neuro-Oncology Advances · Dec 13, 2024Peer-reviewedCancer Biology