Benjamin Schuster‐Böckler

Rastair is a tool for simultaneous SNP detection and methylation calling from mC→T sequencing data, achieving high accuracy and speed.

This study shows SHH-MB cells in co-culture with cerebellar organoids adopt patient tumor-like phenotypes and heterogeneity, suggesting microenvironment-driven malignant states.

The paper characterizes genetic determinants of context-specific DNA methylation in primary monocytes exposed to inflammatory stimuli, identifying 209 CpGs under genetic control and linking them to disease.

The paper shows that cytosine methylation affects mutation rates at neighboring nucleotides differently in humans, Arabidopsis, and rice, with species-specific patterns.

This paper introduces a bisulfite-free method for base-resolution sequencing of 5mC and 5hmC, offering higher quality and lower cost compared to traditional bisulfite sequencing.

The paper uses single-cell RNA-seq to compare Barretts esophagus with normal esophageal tissues, finding transcriptional similarities with esophageal cells but not with gastric or duodenal cells.

BEARscc improves single-cell RNA-seq clustering by simulating technical replicates using RNA spike-ins to reduce technical variance.