Author

John Jacob

University of OxfordORCID 0000-0002-7285-3526Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:clustering· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Esther B. E. BeckeriD· 2 shared Max J. van EsseniD· 2 shared Alina NicheperovichiD· 1 shared Benjamin Schuster‐BöckleriD· 1 shared Elizabeth J. ApsleyiD· 1 shared Joey RiepsaameiD· 1 shared Paul A. NorthcottiD· 1 shared Ruijie XuiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 26 mutual co-author links

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2 shared papersCancer Biology

Esther B. E. BeckerORCID

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2 papers

Recent·Most cited

Sonic hedgehog medulloblastoma cells in co-culture with cerebellar organoids converge towards in vivo malignant cell states

Max J. van Essen, Alina Nicheperovich, Benjamin Schuster‐Böckler, Esther B. E. Becker, John Jacob

This study shows SHH-MB cells in co-culture with cerebellar organoids adopt patient tumor-like phenotypes and heterogeneity, suggesting microenvironment-driven malignant states.

Neuro-Oncology Advances · Dec 13, 2024Peer-reviewedCancer Biology

PTCH1 mutant human cerebellar organoids are associated with altered neural development and early pathways of medulloblastoma oncogenesis

Max J. van Essen, Elizabeth J. Apsley, Joey Riepsaame, Ruijie Xu, Paul A. Northcott, Sally A. Cowley, John Jacob, Esther B. E. Becker

This study uses human iPSC-derived cerebellar organoids to investigate how PTCH1 mutations affect neural development and early medulloblastoma pathways.

Disease Models & Mechanisms · Feb 1, 2024Peer-reviewedNeuroscience