Esther B. E. Becker

Enhanced mGluR1 function causes motor deficits and region-specific Purkinje cell dysfunction

This study shows that enhanced mGluR1 function causes motor deficits and region-specific Purkinje cell dysfunction in a mouse model of SCA44.

Structural mechanism of TRPC3 inhibition by a potent and selective antagonist

This study identifies a potent and selective TRPC3 inhibitor, GSK2820986A, and elucidates its binding mechanism through molecular dynamics and functional assays.

Cerebellar organoids model cell type-specific FOXP2 expression during human cerebellar development

This study uses cerebellar organoids to model FOXP2 expression in early human cerebellar development and identifies its targets and associated neurodevelopmental vulnerabilities.

Sonic hedgehog medulloblastoma cells in co-culture with cerebellar organoids converge towards in vivo malignant cell states

This study shows SHH-MB cells in co-culture with cerebellar organoids adopt patient tumor-like phenotypes and heterogeneity, suggesting microenvironment-driven malignant states.

PTCH1 mutant human cerebellar organoids are associated with altered neural development and early pathways of medulloblastoma oncogenesis

This study uses human iPSC-derived cerebellar organoids to investigate how PTCH1 mutations affect neural development and early medulloblastoma pathways.

Single-cell sequencing of human iPSC-derived cerebellar organoids shows recapitulation of cerebellar development

The paper develops a method to generate cerebellar organoids from human iPSCs and shows they recapitulate key aspects of cerebellar development through single-cell profiling.

TRPC3 is essential for functional heterogeneity of cerebellar Purkinje cells

This study shows TRPC3 is essential for functional heterogeneity in cerebellar Purkinje cells by affecting simple and complex spike activity and behavior related to specific modules.