Long-lasting Analgesia via Targeted in vivo Epigenetic Repression of Nav1.7
Ana M. Moreno, Glaucilene Ferreira Catroli, Fernando Alemán, Andrew Pla, Sarah A. Woller, Michael Y. Hu, Tony L. Yaksh, Prashant Mali
This study develops a method to achieve long-lasting, non-addictive pain relief by epigenetically repressing NaV1.7 in vivo using CRISPR-dCas9 and zinc finger proteins.
bioRxiv · Jul 24, 2019 · PreprintGenetics